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KMID : 0359319970370030619
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Korean Journal of Veterinary Research
1997 Volume.37 No. 3 p.619 ~ p.627
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Effects of red ginseng total saponin on Menadione-induced hepatotoxicity in the rat
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Jang Bong-Jun
Bae Chun-Sik
Cho Young-Sung
Cha Yong-Ho
Park Chang-Won
Choi Dae-Hyun
Chang Kyung-Jin
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Abstract
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It is known that 2-methyl-1,4-naphtoquinone(menadione, MD) induces hepatotoxicities both in vivo and in vitro. These toxic effects are believed to result from oxidative damages to hepatocytes by "active oxygen" species via one-electron reduction of the naphtoquinone. The ginsenoside(GS) is a complex mixture of individual ginsenosides which is known to produce a range of effects on the cardiovascular and central nervous systems. In particular, GS has an antioxidant effect. In this experiment we studied the effect of GS from red panax ginseng(red ginseng total saponin, RGTS) on free radical-induced liver injuries by MD. Administration of MD(150μM) caused an increase in aspartate aminotransferase(AST) activities and lipid peroxidation, decrease in alkaline phosphatase(ALP) activities and total bilirubin levels in blood, caused depletion of GSH and changes of antioxidant enzyme(superoxide dismutase, catalase) activities are shown in liver tissue. Administration of RGTS restored the AST levels that increased by MD, but catalase showed no significant changes. RGTS also had an effect of restoring the GSH level and had some synergistic effects with SOD. These data suggest that RGTS may have some protective effects on liver injury which is related with the oxygen free radical.
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KEYWORD
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menadione , liver , toxicity , ginsenoside , antioxidant effect
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